Our lab’s mission is to understand immune defense quantitatively using theory and computation.
Our research integrates mathematical modelling, machine learning, and immunology to decode the fundamental principles governing adaptive immune responses. By combining theoretical approaches with data-driven methods, we aim to uncover how immune repertoires evolve, respond to challenges, and contribute to disease pathology.
We are a research group in the Division of Infection and Immunity at UCL. Our approach to quantitative immunology is rooted in the tradition of biological physics and we are also part of the Institute for the Physics of Living Systems. Our research is embedded within the collaborative environment of the Innate2Adaptive lab group and we have strong links with experimental and theory groups at UCL and beyond.
You can find an overview of our research philosophy and research interests here or you can take a look at some of our recent publications. And finally, we have an open door policy for all of our lab meetings, so if you want to get a first-hand impression of what research questions we are most excited by at the moment email us and come stop by!
Selected News
- November 2024: Congratulations to Yuta on being runners up for the IJEP Woolf Prize for best MBPhD thesis at UCL!
- October 2024: Congratulations to Dr. Yuta Nagano for his successful PhD defense!
- July 2024: Our Wellcome Discovery Team Award was funded enabling us to study the clonal and functional T cell determinants of protection and pathogenesis in tuberculosis for the next eight years.
- March 14th 2024: We organised the 2nd London Quantitative Immunology Day.
- January 2024: The London Quantitative Immunology Network now has a mailing list: Sign up instructions here.
- December 2024: Our Type 1 Diabetes Grand Challenge award was funded enabling us to study mathematically how combination immunotherapies impact different immune cells involved in this autoimmune disease.
- December 2023: Silver and Bronze for the Q-Immuno lab in the IMMREP23 TCR Specificity Prediction Challenge!
- August 6 - 27, 2023: We co-organized a workshop on “Statistical physics and adaptive immunity” at the Aspen Center for Physics.
- March 9th 2023: We organized the 1st London Quantitative Immunology Day.
- July 25 2022: First paper from lab out on bioRxiv! Our first foray into deciphering TCR specificity quantitatively.
- Apr 7 2022: The lab opens its doors at UCL!
- Mar 15 2022: Andreas gave an invited talk at the APS march meeting in the Sensing chemical spaces session.
- Mar 5 2020: Andreas gave an invited (virtual) talk at the APS march meeting in the Population dynamics in time-varying environments session.
- December 11-13 2019: We organized a conference at PCTS on Sensing chemical spaces. Video recordings of the lectures are available here.
Selected Publications
A Mayer, C Callan Measures of epitope binding degeneracy from T cell receptor repertoires, PNAS, 2023.
H Chen, A Mayer, V Balasubramanian A scaling law in CRISPR repertoire sizes arises from avoidance of autoimmunity, Current Biology, 2022.
MG Gaimann, M Nguyen, J Desponds, A Mayer, Early life imprints the hierarchy of T cell clone sizes, eLife, 2020.
A Mayer, Y Zhang, AS Perelson, NS Wingreen, Regulation of T cell expansion by antigen presentation dynamics, PNAS, 2019.
A Mayer, O Rivoire, T Mora, and AM Walczak, Diversity of immune strategies explained by adaptation to pathogen statistics, PNAS, 2016.
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